Premature thelarche: clinical and laboratorial assessment by immunochemiluminescent assay.

Premature Thelarche in Later Childhood Demonstrates a Pubertal Response to GnRH Stimulation Test at One Year after Breast Development

Premature thelarche in later childhood (such as at 5-7 yr of age) is not always easy to distinguish from GnRH-dependent precocious puberty. In this study, a GnRH stimulation test was performed on 21 girls from 5 to 7.5 yr of age with early breast development. In 8 of 11 girls within 1 yr after thelarche, i.e., breast development, the GnRH stimulation test showed a prepubertal response, and in a...

Is Premature Thelarche in the First Two Years of Life Transient?

OBJECTIVE Premature thelarche (PT) refers to isolated onset of thelarche in girls younger than 8 years of age. Most cases have an onset under 2 years of age. We aimed to establish whether the onset of thelarche under 2 years of age certifies a transient clinical course, as suggested by several authors. METHODS Sixty-seven girls with an onset of PT under 2 years of age were classified as havin...

Breast Ultrasonographic Assessment of Premature Thelarche : Preliminary study of correlation with Bone Age and Precocious Puberty

Serum bisphenol A concentration and premature thelarche in female infants aged 4-month to 2-year old

OBJECTIVES To estimate the association between serum bisphenol A and premature thelarche in female infants aged 4-mo to 2-y. METHODS A total of 251 female infants (aged 4 mo to 2 y) with premature thelarche and 33 healthy age-matched control subjects were analyzed. All participants underwent physical examination and serum bisphenol A was measured by ultra-performance liquid chromatography tan...

Etiologies of precocious puberty: 15-year experience in a tertiary hospital in southern Thailand.

BACKGROUND Precocious puberty (PP) is defined as the appearance of secondary sex characteristic at an age <8 years in girls and <9 years in boys, or menarche <9 years in girls. OBJECTIVE To determine the etiologies and clinical characteristics of children presenting with PP. SUBJECTS AND METHOD The medical records of 307 children (292 girls, 15 boys) with PP (1995-2009) were reviewed. RES...